7) Yutaka Kobayashi, Maki Ichioka, Tomoyasu Hirose, Kenichiro Nagai, Atsuko Matsumoto, Hidehiro Matsui, Hideaki Hanaki, Rokuro Masuma, Yoko Takahashi, Satoshi Ōmura and Toshiaki Sunazuka
Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities.
Bioorg. Med. Chem. Lett. 2010, 20, 6116-6120.

6) Ayumi Tsutsui, Yujiro Furuya, Tomoyasu Hirose, Riyon Kim, Rokuro Masuma, Atsuko Matsumoto, Yoko Takahashi, Aki Ishiyama, Miyuki Namatame, Kazuhiko Otoguro, Satoshi Ōmura and Toshiaki Sunazuka
Boromycin derivatives: synthesis and antimalarial activity in vitro and in vivo.
Heterocycles 2010, 82, 289-295. special issue dedicated to Professor Albert Eschenmoser

5) Gouda H.; Sunazuka T.; Hirose T.; Iguchi K.; Yamaotsu N.; Sugawara A.; Noguchi Y.; Saito Y.; Yamamoto T.; Watanabe T.; Shiomi K.; Ōmura S. and Hirono S.
NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.
Bioorg. Med. Chem. 2010, 18, 5835-5844.

4) Nagai T.; Shimizu Y.; Shirahata T.; Sunazuka T.; Kiyohara H;. Ōmura S. and Yamada H.
Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata.
Int Immunopharmacol. 2010, 10, 655-661.

3) Shirahata T.; Matsuo J.; Teruya S.; Hirata N.; Kurimoto T.; Akimoto N.; Sunazuka T.; Kaji E. and Ōmura S.
Improved catalytic and stereoselective glycosylation with glycosyl N-trichloroacetylcarbamate: application to various 1-hydroxy sugars.
Carbohydr. Res. 2010, 345, 740-749.

2) Tomoyasu Hirose, Toshiaki Sunazuka and Satoshi Ōmura
Recent development of two chitinase inhibitor, Argifin and Argadin, produced by soil microorganisms
Proc. Jpn. Acad., Ser. B, 2010, 86, 85-102.

1) Namikawa H., Sunazuka T., Kitamura Y., Suzuki T., Hamasaki Y., Yamazaki S., Ōmura S., Hatamochi A.
Effect of erythromycin A and its new derivative EM201 on type I collagen production by cultured dermal fibroblasts.
Arch Dermatol Res. 2010, 302, 341-348.

9) Ohshiro T., Matsuda D., Nagai K., Doi T., Sunazuka T., Takahashi T., Rudel L. L., Ōmura S. and Tomoda H.
The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA: cholesterol acyltransferase.
Chem. Pharm. Bull. 2009, 57, 377-381.

8) Yasuhiro Kojima , Toshiaki Sunazuka, Kenichiro Nagai, Tomoyasu Hirose, Miyuki Namatame , Aki Ishiyama , Kazuhiko Otoguro and Satoshi Ōmura
Solid-phase synthesis and biological activity of malformin C and its derivatives
J. Antibiot. 2009, 62, 681-686.

7) Hiroaki Gouda, Shinichi Terashima, Kanami Iguchi, Akihiro Sugawara, Yoshifumi Saito, Tsuyoshi Yamamoto, Tomoyasu Hirose, Kazuro Shiomi, Toshiaki Sunazuka, Satoshi Ōmura and Shuichi Hirono
Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.
Bioorg. Med. Chem. 2009, 17, 6270-6278.

6) Tomoyasu Hirose, Toshiaki Sunazuka, Akihiro Sugawara, Yoshihiko Noguchi, Toshiaki Tanaka, Kanami Iguchi, Tsuyoshi Yamamoto, Hiroaki Gouda, Kazuro Shiomi and Satoshi Ōmura
Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin.
J. Antibiot. 2009, 62, 495-500.

5) Tsuyoshi Teramoto, Tamihide Matsunaga, Mie Toba, Toshiaki Sunazuka, Satoshi Ōmura and Shigeru Ohmori
Role of Dexamethasone and Oncostatin M on the Formation of Vacuoles in Human Fetal Liver Cells.
Biol. Pharm. Bull. 2009, 32, 209-212.

4) Tomoyasu Hirose, Toshiaki Sunazuka, Akihiro Sugawara, Ayako Endo, Kanami Iguchi, Tsuyoshi Yamamoto, Hideaki Ui, Kazuro Shiomi, Takeshi Watanabe, K. Barry Sharpless and Satoshi Ōmura
Inhibitors of Chitinase: the Extraction of Active Frame from Natural Product Argifin and Using In Situ Click Chemistry.
J. Antibiot. 2009, 62, 277-282.

3) Hiroaki Gouda, Toshiaki Sunazuka, Kanami Iguchi, Akihiro Sugawara, Tomoyasu Hirose, Yoshihiko Noguchi, Yoshifumi Saito, Yuichi Yanai, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi,Satoshi Ōmura and Shuichi Hirono
Computer-aided rational molecular design of argifin-derivatives with more potent inhibitory activity against chitinase B from Serratia marcescens.
Bioorg. Med. Chem. Lett. 2009, 17, 2630-2633.

2) Toshiaki Sunazuka, Akihiro Sugawara, Kanami Iguchi, Tomoyasu Hirose, Kenichiro Nagai, Yoshihiko Noguchi, Yoshihumi Saito, Hiroaki Gouda, Tsuyoshi Yamamoto, Hideaki Ui, Kazuro Shiomi and Satoshi Ōmura
Argifin; Efficient Solid Phase Total Synthesis and Unexpected Discovery of potent Acyclic peptides.
Bioorg. Med. Chem. 2009, 17, 2751-2758.

1) Shimamura, Hiroyuki; Gouda, Hiroaki; Nagai, Kenichiro; Hirose, Tomoyasu; Ichioka, Maki; Furuya, Yujiro; Kobayashi, Yutaka; Hirono, Shuichi; Sunazuka, Toshiaki and Ōmura, Satoshi
Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE.
Angew. Chem. Int. Ed. 2009, 48, 914-917.

12) Hirose, Tomoyasu; Sunazuka, Toshiaki; Tsuchiya, Satoshi; Tanaka, Toshiaki; Kojima, Yasuhiro; Iwatsuki, Masato and Ōmura, Satoshi
Total Synthesis and Determination of the Absolute Configuration of Guadinomines B and C2.
Chem. Eur. J. 2008, 14, 8220-8238.

11) Ohshiro, Taichi; Ohte, Satoshi; Matsuda, Daisuke; Ohtawa, Masaki; Nagamitsu, Tohru; Sunazuka, Toshiaki; Harigaya, Yoshihiro; Rudel, Lawrence L.; Ōmura, Satoshi and Tomoda, Hiroshi
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.
J. Antibiot. 2008, 61, 503-508.

10) Komuro, Iwao; Sunazuka, Toshiaki; Akagawa, Kiyoko S.; Yokota, Yasuko; Iwamoto, Aikichi and Ōmura, Satoshi
Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPβ.
Proc. Nat. Acad. Sci. USA. 2008, 105, 12509-12514.

9) Nagai, Kenichiro; Doi, Takayuki; Ohshiro, Taichi; Sunazuka, Toshiaki; Tomoda, Hiroshi; Takahashi, Takashi and Ōmura, Satoshi
Synthesis and biological evaluation of a focused library of beauveriolides.
Bioorg. Med. Chem. Lett. 2008, 18, 4397-4400.

8) Yu, ChangHe; Azuma, Arata; Li, YingJi; Wang, Chunyan; Abe, Sinji; Usuki, Jiro; Matsuda, Kuniko; Kudoh, Shoji; Sunazuka, Toshiaki and Ōmura, Satoshi
EM703, A NEW DERIVATIVE OF ERYTHROMYCIN, INHIBITS TRANSFORMING GRWTH FACTOR-β SIGNALING IN HUMAN LUNG FIBROBLASTS.
Experimental Lung Research 2008, 34, 343-354.

7) Kojima, Yasuhiro; Sunazuka, Toshiaki; Nagai, Kenichiro; Julfakyan, Khachatur; Fukuda, Takashi; Tomoda, Hiroshi and Ōmura, Satoshi
Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.
J. Antibiot. 2008, 61, 297-302.

6) Matsumaru, Takanori; Sunazuka, Toshiaki; Hirose, Tomoyasu; Ishiyama, Aki; Namatame, Miyuki; Fukuda, Takashi; Tomoda, Hiroshi; Otoguro, Kazuhiko and Ōmura, Satoshi
Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B.
Tetrahedron 2008, 64, 7369-7377.

5) Iwatsuki, Masato; Uchida, Ryuji; Yoshijima, Hitomi; Ui, Hideaki; Shiomi, Kazuro; Kim, Yong-Pil; Hirose, Tomoyasu; Sunazuka, Toshiaki; Abe, Akio; Tomoda, Hiroshi and Ōmura, Satoshi
Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II. Physico-chemical properties and structure elucidation.
J. Antibiot. 2008, 61, 230-236.

4) Sunazuka, Toshiaki; Shudo, Hiroko; Nagai, Kenichiro; Yoshida, Kiminari; Yamaguchi, Yukie; Hanaki, Hideaki and Ōmura, Satoshi
4'''-N-demethylspiramycin derivatives: Synthesis and evaluation of effectiveness against drug-resistant bacteria.
J. Antibiot. 2008, 61, 175-184.

3) Gouda, Hiroaki; Yanai, Yuichi; Sugawara, Akihiro; Sunazuka, Toshiaki; Ōmura, Satoshi and Hirono, Shuichi
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.
Bioorg. Med. Chem. 2008, 16, 3565-3579.

2) Ikeda, Hideyuki; Sunazuka, Toshiaki; Suzuki, Hiromi; Hamasaki, Yoichiro; Yamazaki, Soji; Ōmura, Satoshi and Hatamochi, Atsushi
EM703, the new derivative of erythromycin, inhibits transcription of type I collagen in normal and scleroderma fibroblasts.
Journal of Dermatological Science 2008, 49, 195-205.

1) Sunazuka, Toshiaki; Hirose, Tomoyasu and Ōmura, Satoshi
Efficient Total Synthesis of Novel Bioactive Microbial Metabolites.
Acc. Chem. Res. 2008, 41, 302-314.

6) Hiroo Hasegawa, Yasuaki Yamada,Kanki Komiyama, Masahiko Hayashi, Masami Ishibashi, Toshiaki Sunazuka, Takeshi Izuhara, Kazuyuki Sugahara, Kazuto Tsuruda, Masato Masuda, Nobuyuki Takasu, Kunihiro Tsukasaki, Masao Tomonaga and Shimeru Kamihira
A novel natural compound, cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy- 12,14 prostaglandinJ2 production.
Blood 2007, 110, 1664-1674.

5) Sugawara, Akihiro; Sunazuka, Toshiaki; Hirose, Tomoyasu; Nagai, Kenichiro; Yamaguchi, Yukie; Hanaki, Hideaki; Sharpless, K. Barry and Ōmura, Satoshi
Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity.
Bioorg. Med. Chem. Lett. 2007, 17, 6340-6344.

4) Sunazuka, Toshiaki; Handa, Masaki; Hirose, Tomoyasu; Matsumaru, Takanori; Togashi, Yuko; Nakamura, Kaoru; Iwai, Yuzuru and Ōmura, Satoshi
Synthesis of the oxa-bridged octalin system of two anti-anaerobe antibiotics, luminamicin and lustromycin.
Tetrahedron Lett. 2007, 48, 5297-5300.

3) Tsuchiya, Satoshi; Sunazuka, Toshiaki; Shirahata, Tatsuya; Hirose, Tomoyasu; Kaji, Eisuke and Ōmura, Satoshi
A new method for efficient coupling of indole and epoxide catalyzed with Yb(OTF)3, and application to the total synthesis of kurasoin B.
Heterocycles 2007, 72, 91-94.

2) Hirose, Tomoyasu; Sunazuka, Toshiaki; Yamamoto, Daisuke; Mouri, Mutsumi; Hagiwara, Yoshiaki; Matsumaru, Takanori; Kaji, Eisuke and Ōmura, Satoshi
Studies toward the total synthesis of irumamycin: stereoselective preparation of the C(15)-C(27) segment via two-directional chain synthesis.
Tetrahedron Lett. 2007, 48, 413-416.

1) Shimamura, Hiroyuki; Sunazuka, Toshiaki; Izuhara, Takashi; Hirose, Tomoyasu; Shiomi, Kazuro and Ōmura, Satoshi
Total Synthesis and Biological Evaluation of Verticipyrone and Analogues.
Org. Lett. 2007, 9, 65-67.

11) Li, Y. J., Azuma, A., Usuki, J., Abe, S., Matsuda, K., Sunazuka, T., Shimizu, T., Hirata, Y., Inagaki, H., Kawada, T., Takahashi, S., Kudoh, S. and Omura, S.
EM703 Improves Bleomycin-induced Pulmonary Fibrosis in Mice by The Inhibition of TGF-β Signaling in Lung Fibroblasts.
Respiratory Research 2006, 7, 16-28.

10) Ui, Hideaki; Shiomi, Kazuro; Suzuki, Hideaki; Hatano, Hiroko; Morimoto, Hiromi; Yamaguchi, Yuichi; Masuma, Rokuro; Sunazuka, Toshiaki; Shimamura, Hiroyuki; Sakamoto, Kimitoshi; Kita, Kiyoshi; Miyoshi, Hideto; Tomoda, Hiroshi and Ōmura, Satoshi
Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083.
J. Antibiot. 2006, 59, 785-790.

9) Hirose, Tomoyasu; Sunazuka, Toshiaki; Noguchi, Yoshihiko; Yamaguchi, Yukie; Hanaki, Hideaki; Sharpless, K. Barry and Ōmura, Satoshi
Rapid 'SAR' via click chemistry: an alkyne-bearing spiramycin is fused with diverse azides to yield new triazole-antibacterial candidates.
Heterocycles 2006, 69, 55-61.

8) Tsuchiya, Satoshi; Sunazuka, Toshiaki; Hirose, Tomoyasu; Mori, Ryuma; Tanaka, Toshiaki; Iwatsuki, Masato and Ōmura, Satoshi
Asymmetric Total Synthesis of (+)-K01-0509 B: Determination of Absolute Configuration.
Org. Lett. 2006, 8, 5577-5580.

7) Monma, Souichi; Sunazuka, Toshiaki; Nagai, Kenichiro; Arai, Takahiro; Shiomi, Kazuro; Matsui, Ryosuke and Ōmura, Satoshi
Verticilide: Elucidation of Absolute Configuration and Total Synthesis.
Org. Lett. 2006, 8, 5601-5604.

6) Shirahata, Tatsuya; Sunazuka, Toshiaki; Yoshida, Kiminari; Yamamoto, Daisuke; Harigaya, Yoshihiro; Kuwajima, Isao; Nagai, Takayuki; Kiyohara, Hiroaki; Yamada, Haruki and Ōmura, Satoshi
Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids.
Tetrahedron 2006, 62, 9483-9496.

5) Hirose, Tomoyasu; Sunazuka, Toshiaki; Yamamoto, Daisuke; Kaji, Eisuke and Ōmura, Satoshi
Synthetic applications of a three-component Mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B.
Tetrahedron Lett. 2006, 47, 6761-6764.

4) Doi, Takayuki; Nagai, Kenichiro; Sekiguchi, Takafumi; Fujimoto, Nobuaki; Namatame, Ichiji; Sunazuka, Toshiaki; Tomoda, Hiroshi; Ōmura, Satoshi and Takahashi, Takashi
Synthesis and biological evaluation of a beauveriolide analogue library.
Peptide Science 2006, 42, 51-52.

3) Yamamoto, Daisuke; Sunazuka, Toshiaki; Hirose, Tomoyasu; Kojima, Naoto; Kaji, Eisuke and Ōmura, Satoshi
Design, synthesis, and biological activities of madindoline analogs.
Bioorg. Med. Chem. Lett. 2006, 16, 2807-2811.

2) Gouda, Hiroaki; Sunazuka, Toshiaki; Yoshida, Kiminari; Sugawara, Akihiro; Sakoh, Yusuke; Ōmura, Satoshi and Hirono, Shuichi.
Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation.
Bioorg. Med. Chem. Lett. 2006, 16, 2496-2499.

1) Nagai, Kenichiro; Doi, Takayuki; Sekiguchi, Takafumi; Namatame, Ichiji; Sunazuka, Toshiaki; Tomoda, Hiroshi; Ōmura, Satoshi and Takahashi, Takashi.
Synthesis and Biological Evaluation of a Beauveriolide Analogue Library.
J. Comb. Chem. 2006, 8, 103-109.

9) Gouda, Hiroaki; Sunazuka, Toshiaki; Ui, Hideaki; Handa, Masaki; Sakoh, Yusuke; Iwai, Yuzuru; Hirono, Shuichi and Ōmura, Satoshi
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method.
Proc. Nat. Acad. Sci. USA. 2005, 102, 18286-18291.

8) Sunazuka, Toshiaki and Ōmura, Satoshi
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites.
Chem. Rev. 2005, 105, 4559-4580.

7) Sunazuka, Toshiaki; Hirose, Tomoyasu and Ōmura, Satoshi
Total synthesis of madindolines, potent selective inhibitors of interleukine 6, novel bioactive microbial metabolites.
Yuki Gosei Kagaku Kyokaishi, 2005, 63, 1090-1101.

6) Matsui, Hidenori; Eguchi, Masahiro; Ohsumi, Katsufumi; Nakamura, Akio; Isshiki, Yasunori; Sekiya, Kachiko; Kikuchi, Yuji; Nagamitsu, Tohru; Masuma, Rokuro; Sunazuka, Toshiaki and Ōmura, Satoshi
Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar Typhimurium.
Antimicrob. Agents Chemother. 2005, 49, 3396-3403.

5) Hirose, Tomoyasu; Sunazuka, Toshiaki; Yamamoto, Daisuke; Kojima, Naoto; Shirahata, Tatsuya; Harigaya, Yoshihiro; Kuwajima, Isao and Ōmura, Satoshi
Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: a practical improvement to a second-generation approach from the first-generation.
Tetrahedron 2005, 61, 6015-6039.

4) Sunazuka, Toshiaki; Hirose, Tomoyasu; Chikaraishi, Noriko; Harigaya, Yoshihiro; Hayashi, Masahiko; Komiyama, Kanki; Sprengeler, Paul A.; Smith, Amos B. and Ōmura, Satoshi
Absolute stereochemistries and total synthesis of (+)/(-)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion.
Tetrahedron 2005, 61, 3789-3803.

3) Sunazuka, Toshiaki; Shirahata, Tatsuya; Tsuchiya, Satoshi; Hirose, Tomoyasu; Mori, Ryuma; Harigaya, Yoshihiro; Kuwajima, Isao and Ōmura, Satoshi
A Concise Stereoselective Route to the Indoline Spiroaminal Framework of Neoxaline and Oxaline.
Org. Lett. 2005, 7, 941-943.

2) Sunazuka, Toshiaki; Yoshida, Kiminari; Kojima, Naoto; Shirahata, Tatsuya; Hirose, Tomoyasu; Handa, Masaki; Yamamoto, Daisuke; Harigaya, Yoshihiro; Kuwajima, Isao and Ōmura, Satoshi
Total synthesis of (-)-physovenine from (-)-3a-hydroxyfuroindoline.
Tetrahedron Lett. 2005, 46, 1459-1461.

1) Yoshida, Kiminari; Sunazuka, Toshiaki; Nagai, Kenichiro; Sugawara, Akihiro; Cho, Achim; Nagamitsu, Tohru; Harigaya, Yoshihiro; Otoguro, Kazuhiko; Akagawa, Kiyoko S. and Ōmura, Satoshi
Macrolides with promotive activity of monocyte to macrophage differentiation.
J. Antibiot. 2005, 58, 79-81.

5) Sunazuka, Toshiaki; Handa, Masaki; Nagai, Kenichiro; Shirahata, Tatsuya; Harigaya, Yoshihiro; Otoguro, Kazuhiko; Kuwajima, Isao and Ōmura, Satoshi
Absolute stereochemistries and total synthesis of (+)-arisugacins A and B, potent, orally bioactive and selective inhibitors of acetylcholinesterase.
Tetrahedron 2004, 60, 7845-7859.

4) Nagai, Kenichiro; Shiomi, Kazuro; Sunazuka, Toshiaki; Harder, Achim; Turberg, Andreas and Ōmura, Satoshi
Synthesis and biological evaluation of novel 4''-alkoxy avermectin derivatives.
Bioorg. Med. Chem. Lett. 2004, 14, 4135-4139.

3) Otoguro, Kazuhiko; Ishiyama, Aki; Kobayashi, Miyuki; Sekiguchi, Hitomi; Izuhara, Takashi; Sunazuka, Toshiaki; Tomoda, Hiroshi; Yamada, Haruki and Ōmura, Satoshi
In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodium.
J. Antibiot. 2004, 57, 400-402.

2) Desaki, Masashi; Okazaki, Hitoshi; Sunazuka, Toshiaki; Ōmura, Satoshi; Yamamoto, Kazuhiko and Takizawa, Hajime
Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: Possible role in the signaling pathway that regulates nuclear factor-κ B activation.
Antimicrob. Agents Chemother. 2004, 48, 1581-1585.

1) Nagai, Kenichiro; Sunazuka, Toshiaki and Ōmura, Satoshi
Synthesis of 4''-alkoxy avermectin derivatives using rhodium carbenoid-mediated O-H insertion reaction.
Tetrahedron Lett. 2004, 45, 2507-2509.

6) Takahashi, Takashi; Kusaka, Shin-ichi; Doi, Takayuki; Sunazuka, Toshiaki and Ōmura, Satoshi.
A combinatorial synthesis of a macrosphelide library utilizing a palladium-catalyzed carbonylation on a polymer support.
Angew. Chem. Int. Ed. 2003, 42, 5230-5234.

5) Nagai, Kenichiro; Sunazuka, Toshiaki; Shiomi, Kazuro; Harder, Achim; Turberg, Andreas and Ōmura, Satoshi
Synthesis and biological activities of novel 4''-alkylidene avermectin derivatives.
Bioorg. Med. Chem. Lett. 2003, 13, 3943-3946.

4) Handa, Masaki; Sunazuka, Toshiaki; Sugawara, Akihiro; Harigaya, Yoshihiro; Otoguro, Kazuhiko and Ōmura, Satoshi
Total syntheses of the AChE inhibitors (±)-arisugacins F and G.
J. Antibiot. 2003, 56, 730-733.

3) Sunazuka, Toshiaki; Yoshida, Kiminari; Oohori, Masako; Otoguro, Kazuhiko; Harigaya, Yoshihiro; Iwai, Yuzuru; Akagawa, Kiyoko S. and Ōmura, Satoshi
Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation.
J. Antibiot. 2003, 56, 721-724.

2) Handa, Masaki; Ui, Hideaki; Yamamoto, Daisuke; Monma, Soichi; Iwai, Yuzuru; Sunazuka, Toshiaki and Ōmura, Satoshi
Structure determination of lustromycin, an antibiotic against anaerobic bacteria.
Heterocycles 2003, 59, 497-500.

1) Shirahata, Tatsuya; Sunazuka, Toshiaki; Yoshida, Kiminari; Yamamoto, Daisuke; Harigaya, Yoshihiko; Nagai, Takayuki; Kiyohara, Hiroaki; Yamada, Haruki; Kuwajima, Isao and Ōmura, Satoshi
Total synthesis and adjuvant activity of all stereoisomers of pinellic acid.
Bioorg. Med. Chem. Lett. 2003, 13, 937-941.

6) Hayashi, Masahiko; Rho, Mun-Chual; Enomoto, Akiko; Fukami, Akiko; Kim, Yong-Pil; Kikuchi, Yuji; Sunazuka, Toshiaki; Hirose, Tomoyasu; Komiyama, Kanki and Ōmura, Satoshi
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.
Proc. Nat. Acad. Sci. USA. 2002, 99, 14728-14733.

5) Nagai, Takayuki; Kiyohara, Hiroaki; Munakata, Kaori; Shirahata, Tatsuya; Sunazuka, Toshiaki; Harigaya, Yoshihiro and Yamada, Haruki
Pinellic acid from the tuber of Pinellia ternata Breitenbach as an effective oral adjuvant for nasal influenza vaccine.
International Immunopharmacology 2002, 2, 1183-1193.

4) Tsuchihashi, Yoshiko; Oishi, Kazunori; Yoshimine, Hiroyuki; Suzuki, Shoichi; Kumatori, Atsushi; Sunazuka, Toshiaki; Ōmura, Satoshi; Matsushima, Kouji and Nagatake, Tsuyoshi
Fourteen-member macrolides suppress interleukin-8 production but do not promote apoptosis of activated neutrophils.
Antimicrob. Agents Chemother. 2002, 46, 1101-1104.

3) Sunazuka, Toshiaki; Shirahata, Tatsuya; Yoshida, Kiminari; Yamamoto, Daisuke; Harigaya, Yoshihiro; Nagai, Takayuki; Kiyohara, Hiroaki; Yamada, Haruki; Kuwajima, Isao and Ōmura, Satoshi
Total synthesis of pinellic acid, a potent oral adjuvant for nasal influenza vaccine. Determination of the relative and absolute configuration.
Tetrahedron Lett. 2002, 43, 1265-1268.

2) Hirose, Tomoyasu; Sunazuka, Toshiaki; Shirahata, Tatsuya; Yamamoto, Daisuke; Harigaya, Yoshihiro; Kuwajima, Isao and Ōmura, Satoshi
Short Total Synthesis of (+)-Madindolines A and B.
Org. Lett. 2002, 4, 501-503.

1) Sunazuka, Toshiaki; Handa, Masaki; Nagai, Kenichiro; Shirahata, Tatsuya; Harigaya, Yoshihiro; Otoguro, Kazuhiko; Kuwajima, Isao and Ōmura, Satoshi
The First Total Synthesis of (±)-Arisugacin A, a Potent, Orally Bioavailable Inhibitor of Acetylcholinesterase.
Org. Lett. 2002, 4, 367-369.